quarta-feira, 10 de junho de 2015


Hi guys,
Today I'm gonna write about sulfotransferases family.
As their name suggest, Sulfotransferases are transferase enzymes that catalyses the transfer reaction of a sulfate group from a donor molecule to an acceptor alcohol or amine. These enzymes add sulfate groups in proteins after translation.
In one of the transcriptomes, from the Pterygoplichthys anisitsi (see our previous post), we found the above members of Sulfotransferases:

We can see that two groups are more abundant: group 1, the carbohydrate sulfotransferases, that are responsible for transfer sulfates to carbohydrate groups in glycoproteins and glycolipids; and the group 2, SULT, that refers to sulfotransferases, are responsible to catalyse the conjugation reaction between sulfate and hormones, neurotransmitters, drugs, and xenobiotics. Its distribution in tissues is different, just as the substrate specificity. Always good to remember, those transcripts were all sequenced just in the liver tissue. It is possible (and most probable) that this fish possess even more sulfotransferases that were not expressed in the liver.

That is all for now, till next time!

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